Isabel Keating’s film roles include ­­­­work with directors James Schamus, Robert Pulcini, Shari Springer Berman, and Vadim Perelman, among others. Her films include Indignation (with Logan Lerman, Sarah Gadon and Tracy Letts), which had its premiere at the Sundance Film Festival; The Life Before Her Eyes (with Uma Thurman and Evan Rachel Wood), and The Nanny Diaries (with Scarlett Johansson and Chris Evans).

Television episodic work includes Season 4, episode 1 of "New Amsterdam" (guest star opposite Tyler Labine, directed by Michael Slovis, producer David Schulner (NBC)) (first airing September 21, 2021), "The Path" (guest star, opposite Rockmond Dunbar (NBC/Hulu)), as well as "3 Lbs." (guest star opposite Stanley Tucci (CBS)), and "Law & Order: Criminal Intent" (guest star opposite Vincent d’Onofrio (NBC)). She provided her voice for the Emmy award-winning PBS American Masters "Judy Garland: By Myself". 

For her work on stage, Isabel was nominated for the Tony Award and received the Drama Desk Award and the Theatre World Award for her performance as Judy Garland, starring opposite Hugh Jackman, in The Boy from Oz on Broadway, for which she was also nominated for the Drama League and Outer Critics Circle Awards. She won the Helen Hayes Award for her performance in Tom Stoppard’s Indian Ink.

Isabel starred on Broadway as Madame Morrible in the long-running hit Wicked the Musical. Alongside Nathan Lane, Matthew Broderick, F. Murray Abraham, Stockard Channing, Rupert Grint and Megan Mullally, she starred in Terrence McNally’s hit It’s Only a Play, directed by Jack O’Brien. Also on Broadway, she starred in Hairspray (also directed by Mr. O’Brien), Spider-Man Turn Off the Dark (directed by Julie Taymor), and Enchanted April (directed by Michael Wilson).

Off-Broadway, she appeared opposite Jennifer Westfeldt in Cusi Cram's A Lifetime Burning for Primary Stages, and with Atlantic Theatre Company, Ensemble Studio Theatre, Rattlestick Playwrights Theatre, and, notably, Watermark Theatre’s U.S. premiere of Lucinda Coxon’s Waiting at the Water’s Edge, directed by Nela Wagman.

She has appeared across the country at such theatres as the Kennedy Center, Arena Stage, The Old Globe, Williamstown Theatre Festival, Long Wharf, the O’Neill Center, Paper Mill Playhouse, and more, in plays by Oscar Wilde, Anton Chekhov, Tony Kushner, Donald Margulies, Lillian Hellman and many others.

She has twice been a finalist for the prestigious Audie Award for audio narration. Her narration of A Woman in Berlin landed her on Audiofile Magazine's Best Audiobooks of 2017 list.

Keating loves creating new work, working with emerging writing talents such as Amy Herzog and Anna Ziegler, among many others, and currently has two plays of her own in development.